Turmeric’s protective effect on rats’ prostate damage caused by aluminum

Farouk BOUDOU; Amal BELAKREDAR; Ahmed RASHID; Layth J. MOHAMMED; Mohammed RASHEED; Malika BENDAHMANE-SALMI; Raad RASHEED

doi:10.55779/nsb17312593

Authors

Farouk BOUDOU University of Science and Technology of Oran – Mohamed-Boudiaf (USTO-MB), Faculty of Biological Sciences, Department of Biology, Oran (DZ) https://orcid.org/0000-0002-6008-3325
Amal BELAKREDAR University of Mostaganem Abdelhamid Ibn Badis, Faculty of Natural Sciences and Life, Department of Biotechnology, Mostaganem, 27000 (DZ) https://orcid.org/0000-0003-0997-690X
Ahmed RASHID Al-Iraqia University Baghdad, College of Arts (IQ)
Layth J. MOHAMMED Al-Iraqia University Baghdad, College of Arts (IQ)
Mohammed RASHEED 1) University of Technology-Iraq, Applied Sciences Department, Al-senaha Street, P.O. Box 19006, Baghdad, Iraq; 2) Universite d’Angers, UMR CNRS 6200, MOLTECH Anjou, 2, Bd Lavoisier, 49045 Angers (FR)
Malika BENDAHMANE-SALMI University of Sidi Bel Abbes, Faculty of Medicine, Research Laboratory of Environment and Health (RLEH), Sidi-Bel-Abbes (DZ)
Raad RASHEED Al-Shirqat General Hospital, Salah Al-Deen Directorate of Health Government, Ministry of Health (IQ)

DOI:

https://doi.org/10.55779/nsb17312593

Keywords:

aluminum toxicity, antioxidant, anti-inflammatory, prostate damage, turmeric

Abstract

In the context of increasing environmental aluminum exposure and its documented reproductive toxicity, this study investigated the protective potential of turmeric (Curcuma longa L.), a natural antioxidant and anti-inflammatory agent, against aluminum-induced prostate damage in a male rat model. Exposure to aluminum chloride (AlCl₃) successfully induced prostatic toxicity, manifested through significantly reduced body weight, elevated oxidative stress markers, decreased serum testosterone levels, increased apoptosis, and pronounced infiltration of pro-inflammatory mast cells. Histopathological examination confirmed substantial alterations in prostate tissue architecture. Co-administration of turmeric extract markedly ameliorated these adverse effects, leading to improved body weight, restoration of testosterone levels, reduction in apoptotic activity, and decreased mast cell infiltration. The findings indicate that the protective mechanism of C. longa is primarily mediated through its potent antioxidant and anti-inflammatory properties. Consequently, turmeric emerges as a promising, naturally sourced therapeutic agent for managing and preventing reproductive disorders, such as prostatitis, associated with exposure to environmental toxicants like aluminum.

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